Stem cell and Unicorn poop!

 

Dear all,  1) STEM CELL FOR MS

stem cell

I thought the Panorama piece about stem cell transplantation (AHSCT, ASCT or HSCT) for MS was well done and respectful to people with MS. You can watch it here: http://www.bbc.co.uk/programmes/b06ss17g ,

and there is very good following information on the MS Trust website at https://www.mstrust.org.uk/a-z/stem-cell-therapy#availability

I’m summarising the main points from that here:

As with most treatments for MS, it is only effective for people with either relapsing remitting, or early progressive MS, for whom inflammation is a feature – ie relapses, or active lesions on MRI scan. It’s an aggressive treatment & has significant risks, including risk of death – now reduced to 1-2 per 100 people treated, due to infection.

In the UK, it’s only been offered as treatment on the NHS so far to a very few people, with very aggressive forms of MS, who have continued to relapse on disease modifying therapies, and in general early in the disease course, before the onset of any permanent disability (although rare exceptions in recent disability within last year)

There is one clinical trial currently recruiting in the UK currently; details here:

https://clinicaltrials.gov/ct2/show/NCT00273364,

There are stem cell treatments going on commercially, which some people have travelled abroad for. Costs are between £30,000 and £85,000. Some clinics may accept people for whom the benefits would not be considered by UK clinicians to balance with the risks, and an important set of questions to ask yourself and the clinics, if you were to consider this, is on the MS Trust site.

Stem cell therapy has the potential to bring significant benefits to some people with MS. It cannot be seen as a cure, as in trials, for some people, progression has continued after around 2 years. Good progress is being made through clinical trials & the outcomes of treatment are improving as more is learned. However, as research is still at an early stage, stem cell therapy is not widely practiced and the results of treatment for a particular person cannot be predicted. The risks should be very carefully considered, including the possibility of treatment-related death,  and weighed up against potential benefits.

 

 

2) UNICORN POOP!

 

Click below to watch

And now, from one of my favourite topics, poo, to another – more poo!This very funny video has a great product to sell – the ‘Squatty Potty’, which gets you in the correct natural position to effectively ‘have your bowels open’, eliminating the U bend kink that puts everything under strain when you sit on a western style toilet. But it’s worth watching just for the handsome prince eating unicorn poop icecream.

All the best! – Miranda

 

 

 

 

 

 

 

 

 

 

 

 

 

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Fasting for MS & Auto-immune disease

Did you see this paper that came out over summer? http://www.sciencedaily.com/releases/2014/06/140605141507.htm

fasting

Explains how, in both laboratory mice and humans, fasting for 2-4 days at a time caused cells in the immune system to first be depleted, with damaged immune cells being destroyed,  being followed, once eating was re-introduced, by stem cell regeneration of new immune cells.

They liken the effect to ‘flipping a regenerative switch’, and the work has implications for people with auto-immune diseases aswell as those going through chemotherapy, or with lowered immune systems.

Wouldn’t it be great if those new immune cells were not programmmed to destroy the body’s own tissues?

Many ancient cultures and systems of medicine used fasting to treat illness, and there are in fact many benefits to intermittent ( obviously not starving yourself, but on & off) fasting, many of which you can read about in the popular book ‘ The Fast Diet’ by Micheal Mosely

I for one am not going to wait. I have found the benefits of intermittent fasting to be excellent since losing loads of weight on the Fast diet a couple of years ago, and I regularly don’t eat until night time. I don’t have an auto-immune disease, but my little 9 year old daughter does. Tonight I’m going to sit down with her and ask if, if I stay with her and we light the fire, get a duvet down, stack up the biggest pile of films and programs, and she can watch as much and as long as she likes, she would go for a 2 day fast to see what happens.

Watch this space.


Journal Reference:

  1. Chia-Wei Cheng, Gregor B. Adams, Laura Perin, Min Wei, Xiaoying Zhou, Ben S. Lam, Stefano Da Sacco, Mario Mirisola, David I. Quinn, Tanya B. Dorff, John J. Kopchick, Valter D. Longo. Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression. Cell Stem Cell, 2014; 14 (6): 810 DOI:10.1016/j.stem.2014.04.014
  2. Chia-Wei Cheng, Gregor B. Adams, Laura Perin, Min Wei, Xiaoying Zhou, Ben S. Lam, Stefano Da Sacco, Mario Mirisola, David I. Quinn, Tanya B. Dorff, John J. Kopchick, Valter D. Longo

    Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse ImmunosuppressionCell Stem Cell, Volume 14, Issue 6, 5 June 2014, Pages 810-823

Functional medicine to heal auto-immune diseases

It’s another ‘lazy’ blog, re-blogging a great piece called ‘How to stop attacking yourself. 9 steps to heal automimmune disease’ by Dr. Mark Hyman. Brings together a lot of familiar themes; the gut, leaky gut and how to heal it, food intolerances, and calming inflammation.

http://drhyman.com/blog/2010/07/30/how-to-stop-attacking-yourself-9-steps-to-heal-autoimmune-disease/#close

When he talks about infectious agents, I agree, but I tend to use SOS-Advance as it blitzes most things without destroying your natural gut flora.

I hope that soon I’ll get a chance to write something fresh – I’ve been photographing my cooking, so expect a recipe section soon!

All the best

Miranda